At a time when everyone including ASUS is cramming the AMD Fusion E-350 APU into netbooks and mini-ITX motherboards to get rid of Atom; the motherboard major saw "bigger" prospects for the E-350, and designed a micro-ATX motherboard based on it. The E35M1-M Pro from ASUS uses AMD Fusion E-350 APU that embeds a dual-core x86-64 processor based on the "Bobcat" architecture with an AMD Radeon HD 6310 DirectX 11 compliant GPU. The processor is backed by the brand new Hudson M1 single-package chipset. The E35M1-M Pro is intended for everything from office PCs to home PCs, and HTPCs. It draws power from conventional 24-pin ATX and 4-pin CPU power connectors, and uses a 3+1 phase VRM.

The CPU and chipset share a heatsink. The CPU is wired to two DDR3 DIMM slots. Expansion slots include one PCI-Express 2.0 x16, one PCI-E x1, and two PCI slots. Storage expansion includes five internal SATA 6 Gb/s and one eSATA 6 Gb/s. Connectivity includes 6-channel HD audio with optical SPDIF output, 7.1 channel audio over HDMI, gigabit Ethernet, two USB 3.0 ports, FireWire, and a number of USB 2.0 ports. ASUS added a bunch of exclusive features that can let you squeeze out the most performance, and manage power consumption.