MSI expanded its entry-level socket LGA1155 motherboard lineup with the B75MA-G43, featuring Intel Small Business Advantage. The micro-ATX board is positioned to be a notch below the B75MA-G45. It features a simpler 5-phase CPU VRM. The CPU socket, which supports 32 nm "Sandy Bridge" and 22 nm "Ivy Bridge" processors, is wired to four DIMM slots, supporting up to 32 GB of dual-channel DDR3 memory, and a PCI-Express 3.0 x16. Other expansion slots include a PCI-Express 2.0 x16 (electrical x4, wired to PCH), and two legacy PCI.

Storage connectivity on the B75MA-G43 includes one SATA 6 Gb/s, and five SATA 3 Gb/s ports. The chipset gives out four USB 3.0 ports, two of which are given out by a standard header, and two at the rear panel. Display connectivity includes DVI, D-Sub, and HDMI. 8-channel HD audio, gigabit Ethernet, PS/2 combo, LPT and COM (by headers), and a number of USB 2.0/1.1 ports make for the rest of it. The B75MA-G43 is expected to be priced under $60.