New project - OET - Outsmart Ebola Together

[twilyth]

http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,37500

Don't know the details yet but hopefully this will be a drug discovery project since a new vaccine is already going through testing - which will move to West Africa in the coming months.

The vaccine uses a chimp adenovirus that doesn't affect humans and spliced in some of the genetic code from Ebola - http://www.nlm.nih.gov/medlineplus/news/fullstory_149671.html

The clinical trial enrolled volunteers aged 18 to 50. Ten volunteers received a low-dose injection of the vaccine, while another 10 received the same vaccine at a higher dose.

Within a day of vaccination, two people who got the higher dose developed a fever, which was "short-lived and easily handled," Fauci said.

"There were no real red flags when it comes to safety," he said.

At two weeks and four weeks following vaccination, the researchers tested the volunteers' blood to determine if anti-Ebola antibodies were generated. All 20 volunteers developed such antibodies within four weeks of receiving the vaccine, but antibody levels were higher in those who received the higher-dose vaccine.

"The results of the vaccine trial are promising and show that this particular vaccine is able to induce protective levels of immunity," said Dr. Amesh Adalja, a senior associate with the Center for Health Security at the University of Pittsburgh Medical Center. "The trial also begins to provide a basis for selecting the optimal dose needed to achieve protection against Ebola."

Two other phase I trials for the vaccine are ongoing in the United Kingdom and Mali, with results expected by year-end, the NIH said.

But based on the success of the Bethesda trial, researchers hope to begin delivering the experimental vaccine to people in Liberia and Sierra Leone within a couple of months, Fauci said.

But even if the vaccine works, not everyone will be able to get it presumably and there's also the chance that it may not be 100% effective. So having drugs that can deal with the virus would still be something worthwhile pursuing. And any antiviral developed would almost certainly have broader applications.

So I guess we'll have to see just what the project will be focusing on.

 

[Peter1986C]

Project has been added to my profiles. Weirdly enough they had the "special requirements" thing that CEP2 has even though the system requirements seem to be quite low. Hence the not working of my project auto-addition.

 

[[Ion]]

Two new projects in two months...impressive!

 

[Norton]

Thanks for the info!

 

[Tallencor]

http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,37500

Don't know the details yet but hopefully this will be a drug discovery project since a new vaccine is already going through testing - which will move to West Africa in the coming months.

The vaccine uses a chimp adenovirus that doesn't affect humans and spliced in some of the genetic code from Ebola - http://www.nlm.nih.gov/medlineplus/news/fullstory_149671.html


But even if the vaccine works, not everyone will be able to get it presumably and there's also the chance that it may not be 100% effective. So having drugs that can deal with the virus would still be something worthwhile pursuing. And any antiviral developed would almost certainly have broader applications.

So I guess we'll have to see just what the project will be focusing on.

I have my doubts about our .Gov's ability to take their heads out of their collective A$$e$ on this subject. An interesting and unbelievable bit of info on 1 of the Ebola vac's here. http://www.thestar.com/news/canada/2014/11/25/the_strange_tale_of_canadas_ebola_vaccine_walkom.html
I am embarrassed that these people are deciding the future of my Country.

 

[[Ion]]

Well, I've finally managed to score about two dozen of the OET WUs....but it doesn't seem like there are very many to be had. Even fewer than the already-elusive UGM WUs. Looks like badge hunting is going to be difficult here.

 

[twilyth]

Check again now. Last night I only had a handful but now I've got about 70 so it seems as if they are starting to flow. I have most of my machines set up to do only OET and UGM right now so maybe that has something to do with it.

BTW - here is the project overview - https://secure.worldcommunitygrid.org/research/oet1/overview.do

It looks like it will be drug discovery focused on the filovirus family that includes Ebola

Outsmart Ebola Together on World Community Grid aims to help researchers at The Scripps Research Institute develop a treatment for Ebola virus. The computational power donated by World Community Grid volunteers is being used to screen millions of candidate drug molecules to identify ones that can disable the Ebola virus.

And from the project details page

In this project, researchers in the Ollmann Saphire laboratory of The Scripps Research Institute in La Jolla, California are using World Community Grid to search for drugs to treat patients infected with the Ebola virus. An antiviral treatment for Ebola could potentially also be used to treat related diseases in the filovirus family, including the Marburg, Sudan and Reston viruses.

 

[[Ion]]

Yeah they're finally showing up in volume now--I have about 30 pages of them downloaded and ready to run now

 

[ThE_MaD_ShOt]

I have 3 of the regular OET wu's and a crap load of the OET Betas.

 

[twilyth]

Weird. I've got 5 pages of betas and 6 pages of regular OETs. But only 2 pages in progress for the betas and 5 for the OETs. So my guess is that we're just mopping up.

 

[manofthem]

Very exciting. Off to edit profiles to get in on this OET action

 

[RCoon]

based on the success of the Bethesda trial

Oh my, if I had known this was working towards the next Elder Scrolls game too, I'd imagine more people would sign up!

 

[HammerON]

I'm in

 

[dhoshaw]

I've added it to my project list.

 

[Arjai]

Interesting post. Feel free to add this type of research, regarding WCG projects to the WCGrid News and Talking Points Thread I started. This is the type of post I was referring to with the "Talking Points" in the title.

 

[twilyth]

I think it's good to give a new project it's own thread to make sure people see it but next time, I'll try to remember to post something there too. I did think about it but I figured that was your thing.

 

[twilyth]

Not sure if I should resurrect this thread or put it in the team thread but I figured I'd keep it topic specific until someone tells me otherwise.

How are you all doing for OET work units? Right now I'm running 94 threads and only have 4 OET wu's in progress. So I'm guessing that these aren't flowing at the moment. Every device profile includes OET and one has just OET so I would expect a few more than 4.

Of those 4, only one was sent today. The other 3 were sent the 9th or earlier.

 

[manofthem]

I haven't checked today; I did check yesterday evening. It seems the most I ever have is 1 wu per pc, but that doesn't meant that the pcs always have one. Too bad too

I think Kai took them all



Edit: just TeamView'd in and the out of the 2 pcs (main rig couldn't connect), only the 4790 has 1wu. Granted, I run very long buffers on my rigs, but still... disappointing.

 

[Norton]

I went through about 60 of them and only have a few left also?

 

[Tallencor]

According to wcg I have returned 11 wu's for OET none at the moment though.

 

[t_ski]

I only had a few in my cache yesterday when I checked

 

[Norton]

Tried to setup my FX-8350 rig for OET only with no luck... nothing available I guess

 

[[Ion]]

2100 done and validated, about 140 ready to crunch.

 

[twilyth]

Only 2 new wu's delivered since yesterday and both of those were on rigs that don't have that project selected exclusively. That rig seems to be getting a mix of FAAH, MCM and UGM only based on what it's received today.

 

[hat]

I only get FAAH, MCM and CEP2... even though everything is checked in my WCG profile online.