Waiting for Vega and HBM2. We've already seen the power savings of HBM1, AMD's top end cards should have excellent watt / performance that should compare to Nvidia.
Even without HBM, Nvidia still is ~50-80% more power efficient.
There will be no need for HBM for Pascal, Vega and possibly Volta for gaming. What matters is real world performance, not theoretical performance figures you'll never get to experience.
Yup, designs are so much more efficient when sticking to powers of 2. Unfortunately the chips can get so large that physical constraints force them to make compromises with the higher end models so we end up with lopsided memory buses and memory amounts.
I guess you mean powers of two
per memory controller. In a GPU each 64-bit memory controller works independently, and it doesn't matter if the total is not a power of two, or even odd for that matter. It is however preferable that the memory capacity and bandwidth is identical for each controller, unlike products like GTX 970, GTX 660 Ti and GTX 660 among others.
The following configurations are unproblematic:
128-bit (2×64-bit)
192-bit (3×64-bit)
256-bit (4×64-bit)
320-bit (5×64-bit)
384-bit (6×64-bit)
…
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"GTX 1080 Ti"* will be an exciting product, and will finally be an "affordable" powerhouse in the Pascal family. If the claims of "10 GB" memory is correct, it will surely be more than enough.
Just like it's big brother Titan, GTX 1080 Ti will feature full performance fp16, with the possibility for great performance gains for games utilizing it. Vega is supposed to get the same feature.
*) Product naming is not confirmed. Personally I think "GTX 1090" will be more suiting, to indicate the gain over GTX 1080.