This should not be happening on the latest Windows 11 version if Microsoft actually patched this. I do not know why this problem is still showing up but only on some computers and not others.
Cinebench is a good benchmark that will show the loss of performance when Defender is busy doing something in the background. My 10850K drops about 1000 points in Cinebench R23 when Counter Control shows that the timers have been set to 0x222.
Here a 5 run test after fresh reboot. I will try CB2x and see but the MT in CPU-Z you can see 2%. also while the ST not seeing it there I normally never see 800 in ST run and now do even if it ends tiny bit below when finished.
Edit here results of CPU-Z, CB20/23.
Defender counters on. 0x222
ST= 796, 796, 793, 797, 795
MT= 7356, 7408, 7408, 7412, 7407
CB20= 6870, 6886, 6870
CB23= 17924, 18275, 18272
Defender counters off. 0x330
ST= 796, 797,797, 799, 800,
MT= 7564, 7559, 7552, 7540, 7554
CB20= 7077, 7091, 7088
CB23= 18579, 18591, 18545
PS: I noticed you can't run the tests from popular BenchMate app as it sets counters to "not used" 0x000 as soon as you run CB2x. You have to go into folder and run CB2x directly, no launcher.
Anyway, it is showing "Defender" 0x222 after a few mins on a fresh boot.