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| System Name | Virtual Reality / Bioinformatics |
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| VR HMD | HTC Vive + Oculus Quest 2 |
| Software | Windows 10 P |
When chromosomes are mentioned, people would usually think of this:
Defined "X" shape that have tons of your DNA wrapped around it.
Also in the past you may have heard about "junk DNA" in your chromosomes. Those are DNA that does not code for proteins.
However that is only part of the grand picture. In your cells, living cells, your chromosomes are more like this shape:
And those 99% of so called "junk DNA" are actually the major player that makes us human. They serves function from making non-coding RNA, to transcription factor buffering, to gene expression regulation.
Think of the protein coding genes are building blocks of like, the legos. Then the rest 99% of non protein coding DNA are the actual "blue prints" or "user manuals" that direct that specific cell to become a human cell. Here we are talking about 3 billion base pairs of ATCG for us human.
If you think that is not impressive enough, then think about this: Each human body have TRILLIONs of cells. Each and every single of these cells share the EXACT SAME genome. That is where the 4D genome and epigenetic regulation comes in to play. Each cell types have a distinct chromosome arrangement and genome structure, allowing only a specific set of genes being expressed into protein.
Going down to single cell level, each cell nucluei functions as a super computer that process input and generate corresponding output. Then factoring in all trillions of these cells coordinate together via intracellular signaling to form a complex multi-cellular organism. On top of that the neurons generating a massive organic network that acts like a quantum computer---our brain.
And all off these magnificent biological event all rise up from a single zygote cell, one set of genome.
As for why studying the 4D genome matters. It is simple. Environmental factors can impact the way the genome is regulated. And such effect can be long lasting for several generations.
I would highly recommend watching this.
Defined "X" shape that have tons of your DNA wrapped around it.
Also in the past you may have heard about "junk DNA" in your chromosomes. Those are DNA that does not code for proteins.
However that is only part of the grand picture. In your cells, living cells, your chromosomes are more like this shape:
And those 99% of so called "junk DNA" are actually the major player that makes us human. They serves function from making non-coding RNA, to transcription factor buffering, to gene expression regulation.
Think of the protein coding genes are building blocks of like, the legos. Then the rest 99% of non protein coding DNA are the actual "blue prints" or "user manuals" that direct that specific cell to become a human cell. Here we are talking about 3 billion base pairs of ATCG for us human.
If you think that is not impressive enough, then think about this: Each human body have TRILLIONs of cells. Each and every single of these cells share the EXACT SAME genome. That is where the 4D genome and epigenetic regulation comes in to play. Each cell types have a distinct chromosome arrangement and genome structure, allowing only a specific set of genes being expressed into protein.
Going down to single cell level, each cell nucluei functions as a super computer that process input and generate corresponding output. Then factoring in all trillions of these cells coordinate together via intracellular signaling to form a complex multi-cellular organism. On top of that the neurons generating a massive organic network that acts like a quantum computer---our brain.
And all off these magnificent biological event all rise up from a single zygote cell, one set of genome.
As for why studying the 4D genome matters. It is simple. Environmental factors can impact the way the genome is regulated. And such effect can be long lasting for several generations.
I would highly recommend watching this.