It's important to note that participating in these crunching/folding efforts, you're not really donating computing assets, you're really donating electricity.
This is nothing new, it's been the same since the birth of distributed computing, like SETI@Home efforts from the Nineties.
The world has plenty of computing muscle, what it doesn't have is enough free electricity.
At least from the viewpoint of an American filing taxes, you are better off donating cash or fully appreciated negotiable securities to a charity rather than crunching/folding on your own PC.
Charities/larger organizations can buy resources at a far more advantageous price (computer gear, electricity, real estate, whatever) than an individual dealing with retail pricing.
And for the American Joe Consumer, at least a donation of cash/negotiable securities can be claimed as an income tax deduction. If you donate CPU cycles with your personal computer, you can't claim any of that. You are basically donating electricity at retail prices running on semiconductors paid at retail.
This is the same myopic behavior of retail cryptocurrency miners. They are better off buying crypto on the open market rather than spending money on electricity to mine it.
Rich people buy ETH on the open market, like buying cotton futures. Peasants mine it on their $1000 GPUs, like buying tractors, real estate, and fertilizer for their cotton fields.
Even if you had a solar array feeding excess power back into the grid, you're better off doing that rather than taking that "excess" power and mining/crunching/folding. The best thing consumers can do is to reduce overall usage.
The scientific organizations who run the research should be paying consumers to run distributed computing software if they run out of processing power. But that's not the case, they have plenty of CPUs, they just don't have the electricity budget. If Organization X wants to look for a cure, they should put CPUs in a place where electricity is very, Very, VERY cheap. And that's not in the typical suburban/urban Western Hemisphere.
Yeah, sure, you might think you are doing some benefit by crunching/folding on your home system but you are better off taking that money and donating it to a properly managed charity.