I have drivers to support it, all my hardware works fine, and I can even use some 32-bit drivers (simpler hardware like webcams, etc. work just fine for me).
In terms of lack of software, 'tis true, there is a bit of a lack of software, but then again, the uptake for 64-bit is a bit low, which explains why that is.
Compatibility with apps, like I mentioned, is perfect (well, apart from GTR, but it hates 64-bit for some reason even though GTL which is basically the same thing works fine on 64-bit, although I play GTR2 anyhow), so using your apps should be fine.
Just for the record, I have found some applications pertaining to image, video and audio editing do run a bit quicker under 64-bit.