hearnia_2k -- what mouse do you use?
Does this mobo have both USB 2.0 and 3.0 ports? What kind of USB port is the mouse plugged in to?
Is this a wired or wireless mouse?
Also, what version is your Windows 10 OS? You listed Build, but version matters more, such as: 1803, 1809, 1903/etc.
EDIT: Okay, seems you are using Windows 10 Insider Preview, Fast channel. And this by design is meant to have some bugs!
Unless your job is to test Windows 10 Insider Preview Fast channel and you get paid for this, then it may be a good idea to switch to Slow channel, which Microsoft recommends anyway.
The advantages of Slow channel are that there should be less bugs in total, and less major/showstopper bugs too.
The disadvantage of Slow channel is it gets updates much less often than Fast channel, so if a certain bug "hits" you, you may need to wait longer for a fix - such as a few weeks, or in extreme cases - even 1-2+ months.
Also, using Slow channel you may not get new features as fast as with Fast channel, but have in mind that those new features may be partially broken in Fast channel when they are first released.
I am on Slow here, and right now some of my USB 3.0 devices (I have lots, mostly external HDDs/SSDs & docking stations) - notably a fast, good USB 3.0 SATA HDD/SSD adapter - simply fail to connect with a Code 10 error, and this has been the case for months now, with no fix in sight.
(It was mentioned at some point as a known issue, but when MS will fix it, or if they even totally forgot about this bug, I don't know.)
EDIT #2: Do you have any special reasons to want to have Insider Preview at all? If not, you can choose to switch back to "RTM/Stable" version by setting the "Stop getting preview builds" option to ON, but this works in such a way that once you set this setting it will then take months for this to happen - you cannot switch until Microsoft allows/decides it can happen.