While the original inquiry could have been worded better, it's important to stress that not everyone here is a native English speaker.
I suggest you Read The Fine Manual for your specific PSU and consider the manufacturer's advice.
For example, here is a page from the owner's manual for a Seasonic GX-650:
View attachment 345671
As you can see the manufacturer suggests pointing the fan vent upward in a standard PC case when Hybrid Mode or fanless mode is used. There are other scenarios that call for specific orientation. Seasonic is careful to suggest reading the owner's manual for the case as well.
A lot of modern PC cases feature a PSU shroud these days. Many have ventilation holes in the shroud to promote air circulation but not all of them do. If a case has a PSU shroud without ventilation holes, you may be better off pointing the PSU fan vent downward (standard orientation) even if you go fanless or hybrid.
Naturally the page posted here is specific for one model of one manufacturer's product lineup and may not be relevant to you if you do not own this component.
Best of luck.
(Disclaimer: I do not use Hybrid Mode with this PSU so it is installed in the normal orientation: PSU fan vent down.)