Sup people?!
Case fans:
front intake: 3x 120mm thermaltake Thunder blade blue fan front intake fans, [had to use a ghetto mod]
Bottom intake 1x120mm thermaltake Thunder blade blue fan,
Top exhaust: 2x120mm Gelid extreme slim profile UV fans,
Rear exhaust: 2x120mm Thermaltake riing 12 fans on water 3.0 Pro AIO kit.
That's should work well under most circumstances but perty close to not having positive air flow. In testing (using a fog machine), have found that intake fans can lose as much as a third or their air flow from inlet filters, the amount depending on how dirty they are .... so 4 fans in, worst case, can result in 4 x 2/3 or 2-2/3 "fan equivalents" blowing in and 3 blowing out. While this slight negative pressure situation is one folks generally worry about with regard to dust, the bigger concern is this. When you do have negative pressure, its not the lil nooks and crannies that are the concern. It's the HUGE rear case grille. And when air comes in to that way, think about the air source ....what's spitting out a significant amount of air right below those openings ?.... your PSU and your GFX card(s). With the fog machine, you can see this quite clearly. In your case, assuming all the fans were equal in air flow / SP... you should be fine as long as filters aren't too dirty ... the slim fans likely push less air so that would help.
1. Front and Bottom Blow In2. Rear Fans Blow Out
3. Side (depends on location and other numbers)
4. Top Blow out out except when 3 in / 2 out ratio cam not be maintained.
Water cooled, as above except rad fans always blow in.... (No CLCs)
I don't understand the performance PC industry's love of push/pull fans. I know of no other industry that does that. The serial fans in servers are there for fault tolerance. Personally, I like filtered intake fans and I'll let the air go out anywhere it wants, although I like an exhaust fan near the CPU.
In air cooled builds, exhaust fans are not a requirement, the rear case grille provides plenty of open exhaust area. For a quiet system, and by that I mean, you can't tell if its on w/ your ears, I look for (1) 140mm case fan for every 75 - 100 watts (for 120mm, 50 - 75 watts) of connected components. (CPU, MoBo, GFX Cards, pumps, drives). The rear fan mount can take an exhaust fan and all else can be intake.
With water cooling, it's a math thing; how many mounts you have versus how much heat you want to remove. Calculate the watts ya need to remove and then look at the rad data to determine how much rad ya need at what fan rpm you are willing to live with
http://www.overclock.net/t/1457426/radiator-size-estimator
As for our builds ... (air cooled)... So let's say the build w/ OC'd X99 CPU and GFX card (CPU, MoBo and 2 GFX card blocks) needs build totals 635 watts and the plan is a 260 + 240mm radiator. About 40% of that "theoretical" heat will not actually be generated as not everything will be at max output at the same time or radiate off the componentry, tubing, radiator shrouds etc into the case, the remaining will need to be handled by the radiator. That leaves 381 watts at a target delta T of 10C. From testing @ MartinsLiquidlabs, we know that @ 1250 rpm, a 240mm will handle 122 watts and a 360 will handle 188 watts ... 310 total. If we stop there, our delta T will rise from 10C to about 12.5C. No bigga deal. Or ... if you add a 2nd fan on each rad mount in push pull, the rad will handle 152 +227 or 389 watts maintaining the 10C delta T target.
In short, push pull on a rasiator will add an extra 30% cooling, depending of course on the type of radiator (low - medium fpi) and the fan designs