...and the flow rate.
High flow rate = small temperature differential.
Low flow rate = higher temperature differential.
If you're getting too hung up on temperature differentials at different points in your loop you probably need higher flow rates, period.
There's a marginal gain to having heat removed from the coolant earlier rather than later in your loop but that's only even relevant during intermittent-load, low-flow scenarios before your loop hits steady state. If you're worrying about temps in your loop you likely need more radiator, airflow over those radiators, or a higher pump speed.