That's the fan/radiator setup I'm using - fans inside in pull orientation, ports on the bottom. How thick is your rad? I'm using a 30mm Corsair XR5 280 with 28mm Arctic P14 fans, and the fit is decently roomy for an SFF case, had no issues routing cables or anything. Performance is also excellent. Had no real issues installing anything (though due to my thicker than normal fans I wasn't able to intall them outside of the rad due to the screws being too short). Putting my loop together in the Meshlicious was far easier than my previous NZXT H200 - partly due to the sandwich layout putting everything near the side panels, meaning no need to stuff your hands into various crevices to reach things.
Speaking of that build, this arrived last night:
According to the specs it's too tall for the Meshy (163mm vs. 155m max), but either PowerColor and SSUPD measure GPU height differently (with/without the PCIe slot included?) or I'm saved by my rad+fan combo not quite reaching the max spec (30+28mm, so 58mm vs. 63mm max). Either way, an entirely nonscientific "hold it as close to in place as you can without removing the current GPU and check" test tells me it will fit. Definitely close, but doable. The GPU is complete, utter and mind-boggling overkill, and I'll likely be undervolting it just to keep the heat in check. Given that my loop handles the 275W of my Fury X fine I'm not worried about thermals, but with this much performance on the table I can gladly sacrifice some for improved efficiency.
Also got my secondary monitor in, settled on an AOC 24P2C - 75Hz 1080p 24" with USB-C and a built-in KVM. Still needs some tuning to match the colors on my old U2711 (the ICC profile I've got loaded for it makes matching difficult), but it's pretty decent. Tried some gaming on it yesterday, and it's pretty blurry (expected), but 75Hz is nice, and for an office monitor I'm happy that it has overdrive modes - medium results in no artifacting that I can see and visibly improves motion clarity. Not a gaming monitor by any stretch of the imagination, but it'll hold me over for the next while until there are more 27-32" HDMI 2.1-compatible UHD120/144 monitors out. And it'll be a huge boon for my office work. Text clarity is great (far better than the U2711 despite the lower DPI), and the matte display coating is sooooo much better (less grainy/sparkly). I haven't noticed any backlight bleed or glow, but I havent' been looking that hard either.