ASUS expanded its socket LGA2066 workstation-class motherboard lineup with the WS C422 Pro SE. The board is physically identical to the WS X299 Pro SE, but is based on the Intel C422 chipset. Designed for single-socket Intel Xeon W ("Skylake-W") processors, this board is targeted at workstation builders who require ECC memory support.

"Skylake-W" is an enterprise variant of the "Skylake-X" silicon, with support for up to 512 GB of ECC quad-channel DDR4 memory. It features up to 18 CPU cores, and is different from the Xeon Scalable "Skylake-SP" silicon. The board supports up to 512 GB of quad-channel DDR4 memory with support for ECC, over its eight memory slots. The rest of its feature-set is identical to that of the WS X299 Pro SE.

In a response to AMD's current uptake in the consumer, HEDT and server markets with its vertical slice of the Zen architecture, Intel has started rebranding their products and image, changing product names and placement in a bid to increase the "freshness" factor of its offerings. E5 and E7 Xeons are gone, with the introduction of a metallic naming scheme: Bronze, Silver, Gold and Platinum are now Intel's Xeon products, and Xeon-W takes the spot as Intel's workstation-oriented product stack. They do this by being - essentially - a conversion of Intel's Core i9 X299 family of processors towards the professional market with inclusion of professional-geared features. And as is usual with Intel, a new chipset - C422 - is needed in order for these to properly function.

The new Xeon-W product family will still make use of the LGA 2066 socket, bringing with them ECC and vPro support. The Xeon-W CPU family will feature 4 to 18 cores, support up to 512GB of ECC RDIMM/LRDIMM memory, support dual 512-bit FMAs, and peak clocks of 4 GHz base and 4.5 GHz Turbo. All the parts will support 48 PCIe 3.0 lanes from the processor,and CPUs in the Xeon-W stack are rated at 140W TDP: with exception of the quad cores, which come in at at 120W. Xeon-W processors only support Turbo Boost 2.0, instead of their Core i9 counterparts' Turbo 3.0.