This board is definitely the best enthusiast Athlon64 motherboard on the market. Period.
It is a quite a step up from the previous LanParty NF4 Series. There are numerous improvements - DFI has definitely listened to the community. If you are into some serious overclocking there are not many other boards that will be able to keep up with this wonderful motherboard. Its performance is outstanding, so are its overclocking features.
The only drawback is the hefty price of $200. I see no reason why this board should be more expensive than the previous boards, except that DFI charges a premium for their world-class engineering. Let's hope DFI comes up with cheaper versions which do not have the extra SATA ports or maybe only one Gigabit Ethernet port.
Should you buy this board if you already have the LanParty NF4? No. I don't think that's worth it. Should you buy this board if you want to have the latest and greatest and money is secondary to you? Absolutely.