Surface
Both main buttons and the rear panel and modular side grips are coated with a soft touch paint, which feels fantastic in the hands. The side grips have some patterned grooves that generate some extra grip, too. The parts under the side panels (which go around to the very front of the mouse) and the bottom of the shell look like they are made out of some kind of aluminium, but they are actually out of plastic as well.
The side buttons and CPI changer have a more glossy finish, and even though the scroll wheel is rubberized, it may be slippery under sweaty hands due to its design.
Build Quality
The overall build quality of the MX780 is superb; there's not a single rattling or squeaking sound anywhere. It looks and feels rock solid even if your grip holds on to the shell extremely hard.
However, there are some negative things I have to mention. First is that the part where the cable comes out of at the front of the mouse is very sharp. This alone would not be a problem, but it can easily touch your mouse pad (or any other surface you're using the mouse on), instantly creating some scratch marks and generating a lot of friction. This can be DIY-fixed with a small mouse skate (like one made for a Logitech G1 or Microsoft IO1.1/WMO) you would apply to that area. Most people, however, look for a mouse that does not need home fixes like this. The other issue I encountered is that the mouse feet are not rounded down enough; they also are kinda sharp. If you have a thick cloth mouse pad, this too can cause some scratching and extra friction.
Weight
The MX780 weighs around 111 grams by default with a few centimeters of cable. There are a total of 9 grams that can be added to the stock weight by inserting the little metal weights underneath the detachable side panels. In my opinion, the stock weight should be a bit lower. It was still usable, but I definitely prefer a lighter mouse, especially when playing first-person shooters. This is of course entirely up to personal preference, but generally, lighter mice tend to strain your wrists less.