Phanteks has been offering dual-system capable cases for a while now, and even the recently launched Phanteks Eclipse P500A can hold a secondary system with a few additional accessories. However, the Enthoo Pro II, which inherits its frame from the Enthoo 719 has been designed from the ground up with the dual-system capability in mind. The chassis thus has two specific target audiences: those who want that second system for twitch streaming, for example, or those who are planning to load up on storage.
The layout of the secondary ITX system is perfect for most scenarios, but those wanting to use the PCIe slot need to buy the special riser cable. For storage, you get the ability to install up to fifteen 2.5" drives, of which up to four can also be 3.5" drives, out of the box, and you may buy additional 3.5" cages if you want more 3.5" drives. This means the Enthoo Pro II has been well balanced around its unique features of storage and dual-system capability—it can hold its own against classic single-system enclosures.
Being a full-tower case, you can expect to get plenty of space for liquid cooling without cutting down on component dimensions. Phanteks has also done an excellent job with allowing for four massive radiators within the Enthoo Pro II. The only aspect you will have to consider when going down this route is the balance between cooling and storage that works best for you. The third unique selling point of the chassis is the high-performance fabric, which is made out of durable nylon fibers. This should make for great airflow with active cooling in the front, but still requires a second layer in a dust filter to keep grime out.
All this means the Phanteks Enthoo Pro II is a flexible and capable chassis, but there are two aspects that rub me the wrong way, with one being more unfortunate than the other: The cheap I/O cover and how poor the panel with the plugs itself looks is in stark contrast to how the rest of the chassis presents itself, which I consider a bigger issue and single possible point of failure. While others may like to see 1–2 fans inside the chassis considering the $140 price point, the Enthoo Pro II is meant to make the dual-system chassis more accessible in comparison to the $190 you will have to spend to get the Enthoo 719. This means you may also go for dual vertical GPUs and optional 5.25" drive bays which are placed sideways.
Overall, the main factors that will draw in potential buyers are the dual-system capability and the cooling potential. For both scenarios, the Enthoo Pro II is a great choice, but it is getting some competition from its own ranks in the Eclipse P500A. If you are not planning to go for two systems in a single chassis or aren't sure you ever will, you should take a close look at the Eclipse P500A instead.