what card do you have and what driver are you using?
MSI R9 290 4G Gaming. I'm using the latest 14.3 Beta. I was playing the game itself earlier and it was crashing on its own. I lowered the clocks down, I've got it at 990/1250 right now and it was running without issue. F@H seems to run without issue, though I do get lock ups from time to time, it's hard to tell if it's the card OC or CPU OC. Going to let it run tonight with the GPU at those lower clocks.