I can think of ONE case in my experience where it is nvme or bust. And that's heavily modded FO4 with vsync decoupled on the load screens.
I got 32GB ram but I didn't know it would come in handy capacity wise. I have started using gimp with a bit more technical knowhow but not enough to know exactly which filter I want to use, so I keep my tests for comparison. I have allowed Gimp to use 75% of my ram and it does. I have 5500+ tabs in firefox and that maxes out my ram if I have both open. The save time on my 850 Evo is like 5min for a 9GB file. U would think because its such a large file it would be hitting the sequential transfer speeds but its not. I've held off on purchasing any NVME. I bought a 860 evo last black friday but that was before I decided to upgrade my PC.
So both my SSDs are Samsung, I'm not adverse to other manufacturers; but I might just get the 980pro even though I've only got evos so far. My RAM is Patriot Viper 4400 (samsung) Bdie, my monitor is a 144Hz Samsung. I believe my first hard drive was a 200GB Samsung spinpoint (
https://www.newegg.com/samsung-spinpoint-p-series-sp2004c-200gb/p/N82E16822152022).