You have some choices for the AVX 512:
You could build a dual intel 8280L, DDR4, on a Asus Sage c621e mobo. Affordable, plenty of 8280 on ebay, even new, and the cpus cost very little, the Asus mobo is 600 on amazon
you could do dual 7773x Epyc on MZ72-HB0, DDR4
you could do dual 9684x Epyc on MZ73-LM0 DDR5
All these mobos allow multi GPU,while the cheaper asus board, whild older design, offers some really nifty Vrock raid option.
All boards offer at least 4 of the u.2 and some u.3 connectivity
Two choices are on DDR4.
all these builds will fit on a a smaller build, no need for anything rack sized.
Get a decent PSU, at least Corsair Ax1600i or Hela 2050R, both PSUs work on 120 and 240
OS choices are Ubuntu or MS Server 2022 data center or 2025 preview (you can auto update tp 2025)
You can do bare metal or VM, kubernetes, token, etc etc.
Soma savviness, and you can go a long way with either choices, and you can build any of these into a relatively small footprint, and low noise.
J