Anno 2205
After the smash-hit Anno 2070 from three years ago, Ubisoft is back with an even more futuristic sim set in the year 2205 in which mankind has colonized the moon beyond scientific expeditions, having established flourishing economies set way up there. In addition to that, you get to build inspirational cities down here on Earth in various climates.
Based on a proprietary game engine, Anno 2205 takes advantage of DirectX 11, and unlike most RTS games, should be fairly taxing on modern graphics hardware owing to just how much more detail there is in the game's design and its models.