A desktop variant of the AMD Radeon RX 5300 XT graphics card surfaced in a specs sheet of an upcoming HP Pavilion desktop model (TP01-0004ng). The listing describes the RX 5300 XT as featuring 4 GB of GDDR5 memory. This is the first instance of an RX 5300 XT in the wild. An older report citing driver files pointed to there being only two RX 5300-series products, the RX 5300 (desktop), and the mobile RX 5300M. The "XT" brand extension could denote a higher CU count than the RX 5300, although the series is still differentiated from the RX 5500-series with cheaper GDDR5 memory.

The RX 5300 series and RX 5500 series are based on a common silicon, the 7 nm "Navi 14," featuring up to 24 RDNA compute units (up to 1,536 stream processors), and a 128-bit wide memory interface that supports up to 8 GB of GDDR6 or GDDR5 memory. AMD hopes to phase out its 14 nm and 12 nm "Polaris 10" and "Polaris 30" chips with "Navi 14." It's possible that the RX 5300 XT is OEM-only, just like the other key component in this HP desktop, the Ryzen 5 3500 6-core/6-thread processor.