After looking at the Fractal Design Define S2 Vision RGB, it should be apparent to the trained eye that the case is essentially an Define S2 with some very small tooling updates and the overall engineering and build quality of the Define S2.
Fractal Design is staying true to its roots, but has added that subtle and extremely well executed element of lighting. I would have loved to see a properly built-in RGB controller as the in-line adapter is simply not very accessible. However, another nice touch are the four 140 mm retail-grade fans within the case, while the original Define S2 only has three. In the RGB variant, you will also find a perfectly installed RGB lighting strip in the ceiling of the enclosure. On top of that, the 3.5" hard-drive cages don't simply look good, but also allow for some interesting cable routing. You now get a fully fledged USB-C port without having to shell out more money for an upgraded I/O panel.
On the interior, the S2 Vision RGB lacks the usual drive bays, so you have the utmost space for large GPUs, plenty of liquid or air cooling, or even bigger E-ATX motherboards, without issue. Those who still want to show off their graphics card are free to buy a PCIe ribbon cable to do so.
Looking at the price, the chassis is definitely not on the cheaper end of the spectrum. With the original S2 selling for US$150 at launch, the non-RGB Vision variant clocks in at US$40 more. That is the premium you are paying for the two additional glass panels, third fan in the front of the case, and updated fan PCB. which seems justified as it could be broken down into US$10 for each glass panel and US$20 for the fan. The step up to the RGB variant may seem a bit on the steep side, but it breaks down to about US$10 extra per fan and another $10 for the RGB controller itself.
Overall, the Fractal Design S2 Vision RGB takes everything that is awesome about the current Define generation, but adds lots of glass and well-placed lighting to the mix—perfect for everyone who really wanted to get a Fractal case, but was craving some RGB lighting elements as well.