While some would say that the whole "4 or more GPU" thing happened several months ago, it wasn't exactly a very clean quad-SLI solution. You could only stick one monitor on it, and good luck if you had a widescreen. Even then, there were features missing, the drivers were buggy, support was sketchy, and there were a lot of rendering problems/crashes. So, SLI 2.0 (after getting a much more marketing-friendly name) will be able to support something it's first version didn't see- three or more GPU's in a single system with no features disabled. Whether or not SLI 2.0 would be able to use one of those cards for physics is yet to be seen.