ASUS expanded its TUF Gaming motherboard series for the AMD platform with the new TUF B450M-Pro Gaming, positioned above its existing TUF B450M-Plus Gaming. This board features a more upscale CPU VRM design, chunkier VRM heatsinks, a more premium onboard audio solution, an additional M.2 slot, and more fan headers than the B450M-Plus Gaming. To begin with, the board features a 10-phase CPU VRM compared to the simpler 6-phase design of the B450M-Plus Gaming. Both areas of the CPU VRM are cooled by visibly bigger heatsinks, while the B450M-Plus Gaming features no heatsink over the VSoC phases. The board draws power from a combination of 24-pin ATX and 8-pin EPS connectors.

ASUS rearranged the expansion slot layout to make room for a second M.2 slot. The upper slot features both PCI-Express 3.0 x4 and SATA 6 Gbps wiring, while the lower slot features PCI-Express 3.0 x2 and SATA 6 Gbps wiring. Both slots use SATA switching logic to divert SATA links from the board's six SATA 6 Gbps ports. The third major area of improvement is the onboard audio solution, which uses a top-grade Realtek ALC1220A CODEC compared to the entry-level ALC887 of the B450M-Plus Gaming. This chip is still wired out to 6-channel analog jacks. There are a couple of additional 4-pin fan headers. The onboard gigabit Ethernet solution is unchanged, driven by a Realtek RTL8111H PHY. The ASUS TUF B450M-Pro Gaming is expected to be priced at USD $99.