Overclocking
The ASUS ROG Maximus XII Extreme showed a fair bit of headroom for overclocking, at least for short runs of wPrime. I was able to achieve 5.2 GHz at 1.38 V core voltage. Overclocking is largely limited by temperature because the 10-core Intel Core i9-10900K will overpower any ambient cooling solution. Depending on settings, the system will either crash or severely drop frequency.
For memory overclocking, the ASUS ROG Maximus XII Extreme did well, reaching 4000 MHz stable at XMP timings and voltages on my Trident Z Neo kit.