The first section deals with the usual monitor-related settings.
Elden Ring supports fullscreen, windowed, and borderless.
If you switch to borderless, you can still adjust the rendering resolution, which lets you hack in a resolution scaling feature. This not only allows upscaling from a lower resolution, but also supersampling. In the case of my 2560x1600 native resolution, I could pick 3840x2400—the game was now super sharp and crisp, and the GPU load went up accordingly, so it works.
While a non-16:9 resolution can be selected, the game will run with black bars on the top and bottom to maintain the 16:9 ratio.
The details setting presets are "Maximum," "High," "Medium," and "Low." The next page has a comparison between those.
The "advanced" screen has lot of additional setting options to further fine-tune performance.
You can completely turn off motion blur.
What you can't turn off is that Elden Ring is locked to 60 FPS. This is not V-Sync, but a framerate limiter.