MSI's GeForce GTX 460 lineup will include a non-reference design graphics card right from the start (when NVIDIA announces the GTX 460), with the company allowing partners to come up with their own product designs. The N460GTX Cyclone 768D5/OC from MSI, as the name suggests, is a GeForce GTX 460 768MB factory-overclocked graphics card, which makes use of MSI's iconic Cyclone GPU cooler. The cooler is made of an aluminum GPU base from which heat is conveyed by two 8 mm thick heatpipes (which MSI calls "Super Pipes"), to two arc-shaped aluminum fin arrays on either sides of an 80 mm fan. The fan also cools a spirally-projecting aluminum fin block right under it.

The N460GTX Cyclone 768D5/OC has clock speeds of 725/1450/900(3600) MHz (core/CUDA core/memory), and makes use of 768 MB of GDDR5 memory across a 192-bit wide memory interface. Based on the 40 nm GF104 GPU, the GeForce GTX 460 packs 336 CUDA cores, DirectX 11 compliance, and can work in tandem with one more of its kind (2-way SLI). Display connectivity includes two DVI and one mini-HDMI. Being an overclocked non-reference model, MSI's card is expected to be costlier than the reference model (which is expected to be priced at $199), and could be out of the 12th of July, when NVIDIA will have its new GPU out.