The RHA MA750 Wireless is based on what the manufacturer calls the Aerophonic Design. From what I've gathered, what they're trying to say with this is that the built-in dynamic speaker drivers (RHA calls them "Model 560.1") offer exceptional clarity. They also claim that the 303F stainless steel construction further improves sonic performance of the headphones.
In order to properly enjoy these, the first order of business is to find the ear tips that fit your ears best. In general terms, I found the single bore silicone ear tips the worst of the bunch as they don't do that great with noise isolation—you will hear your surroundings and whatever you are listening to will leak out. The dual flange ear tips work much better in both of those regards, while at the same time increasing the snugness of the fit. My favorite ear tips, though, turned out to be the Comply foam ones. They offer great isolation, good comfort, and a tight fit, and all of that is exactly what you want to have for your in-ear headphones to unfold their full potential. If you never used Comply foam ear tips before, you'll be interested to know that they need to be rolled between the fingers before insertion. That compresses them and makes them easier to push inside the ear canal. After they're properly inserted, the foam will expand and seal the ear canal.
The general sound signature of the RHA MA750 Wireless is nicely balanced. They don't go overboard in any part of the frequency range. The bass is very present but not overwhelming, and there's no harshness that could pierce the ears or cause ear fatigue in the upper frequencies. Both male and female vocals of all ranges sound great and blend in nicely with the music. There's plenty of detail and dynamics to be heard in almost any music genre you're listening to. The clarity and openness of the sound are only decent. I'm not going to go as far as to say that your music will sound muffled, but in genres like rock, heavy metal, or anything else that's heavily guitar-driven, a bit more airiness would go a long way towards enhancing the overall experience.
Blink-182's "All the Small Things" is a great song for revealing problems with instrument separation and the interpretation of more subtle details in a guitar-heavy environment. This is where the RHA MA750 Wireless gets somewhat overwhelmed. While the drum breaks are interpreted with a satisfying amount of punch and precision, the song's chorus sounds a bit messy and overly stuffed in the guitar department. With the soundstage a bit more open, one could make more sense of what the guitars are playing.
Practically the same can be said for "Learn to Fly" by Foo Fighters. The drum track and bass line both sound good and give the song a nice feeling of rhythm and flow, with Dave Grohl's vocals sounding distinctive and powerful. However, there's an obvious lack of clarity in the way the guitars blend in with the cymbals, especially audible when you crank the volume as far as it will go (which is more than loud enough for any use).
After switching to something that's not as guitar-driven, things immediately change for the better. In Post Malone's "Rockstar", you'll be greeted by a thick, deep, and punchy bass, one that never spills into the mid-range, at least not to an extent that could negatively impact the clarity of the vocals. Songs like these sound terrific on the RHA MA750 Wireless. It's almost like you put on a different, much more exciting pair of headphones compared to when you use them for rock or metal music.
The vast difference between what I experienced with rock and hip-hop music made me want to check out how the RHA MA750 Wireless deals with music that features guitars but isn't heavy on cymbals. One great example of that is Gábor Szabó's "Galatea's Guitar". After a short acoustic guitar and cello intro, a magnificent rhythm section joins in and beautifully follows the virtuoso guitar player. A wonderful play between the guitars, drums, double bass, cello, vibraslap, rattles, French horn, and several other percussion instruments ensues, creating a truly marvelous piece of music. The RHA MA750 Wireless handles this piece wonderfully. It sounds rich, smooth, musical, and exciting. As long as there are no excessive cymbals and distorted (electric) guitars in sight, these headphones sound great.
Massive Attack and Hope Sandoval (of Mazzy Star fame) recorded a song called "The Spoils", which will tell you a lot about how your headphones or speakers handle exceptionally deep bass, which plays practically throughout the entire song with various electronic and string instruments, and Hope Sandoval's mesmerizing voice as a layer on top of it all. Here, the RHA MA750 Wireless demonstrated a slight hint of boominess and sluggishness in the deepest part of the frequency range. Despite that, the song still sounded coherent and exciting, and the focus was never taken from Hope's singing, which only fortified my impression that the MA750 Wireless really has a lot to offer in terms of sound quality, particularly in the mid-range.
Mogwai's "Kids Will Be Skeletons" that was recently featured in one of the most heartbreaking video game scenes of all time, at the end of Life is Strange's third episode, is yet another multilayered, guitar-heavy song that can, as it builds up, choke out a pair of speakers or headphones that aren't balanced well. If any part of the frequency spectrum sticks out too much, you simply won't be able to hear everything's that happening in this piece. The RHA MA750 Wireless again does a great job of interpreting this demanding song, both in terms of dynamics and instrument separation. One thing to note is that, again, this song doesn't contain traditional cymbals.
If you're interested in pairing the RHA MA750 Wireless with a high-quality external DAC/amplifier, you've come to the wrong place. The digital-to-analog conversion and signal amplification is taken care of by the headphones themselves. There's no way to establish a wired connection with an external device. To be clear, I don't see this as a drawback as these headphones simply aren't made for wired operation.