MSI kicked off its GeForce GTX 650 Ti Boost lineup with two no less than four models, two of which are based on its 100 mm Propeller Blade cooling solution; and two on its Twin Frozr III cooler, which are branded under its Gaming Series. The series begins with the N650Ti-2GD5 BE, which features NVIDIA-reference clock speeds of 980/1033/6008 MHz (core/GPU Boost/memory), and the N650Ti-2GD5/OC BE, which ups clock speeds to 1006/1072/6008 MHz, while retaining the Propeller Blade cooling solution. The Gaming Series variants consist of the N650Ti TF 2GD5 BE, which sticks to NVIDIA-reference clock speeds; and the N650Ti TF 2GD5/OC BE, with a significant factory-overclock of 1033/1098/6008 MHz.

Based on the 28 nm GK106 silicon, the GeForce GTX 650 Ti Boost features 768 CUDA cores, 64 TMUs, 24 ROPs, and a 192-bit wide GDDR5 memory interface, holding 2 GB of memory. The company did not release pricing.