According to the latest investigation made by a German publication, Igor's Lab, AMD's Adrenalin GPU software could experience unexpected behavior when Ryzen Master software is integrated into it. Supposedly, the combination of the two would allow AMD Adrenalin GPU software to misbehave and accidentally change CPU PBO and Precision Boost settings, disregarding the user's permissions. What Igor's Lab investigated was a case of Adrenalin software automatically enabling PBO or "CPU OC" setting when applying GPU profiles. This also happens when the GPU is in the Default mode, which is set automatically by the software.

Alterations can happen without user knowledge. If a user applies custom voltage and frequency settings in BIOS, Adrenalin software can and sometimes will override those settings to set arbitrary ones, potentially impacting the CPU's stability. The software can also alter CPU power limits as it has the means to do so. This problem only occurs when AMD CPU is combined with AMD GPU and AMD Ryzen Master SDK is installed. If another configuration is present, there is no change to the system. There are ways to bypass this edge case, and that is going back to BIOS to re-apply CPU settings manually or disable PBO. A Reddit user found that creating new GPU tuning profiles without loading older profiles will also bypass Adrenalin from adjusting your CPU settings. AMD hasn't made comments about the software, and so far remains a mystery why this is happening.